Solving a Levinthal's paradox for virus assembly identifies a unique antiviral strategy.

@article{Dykeman2014SolvingAL,
  title={Solving a Levinthal's paradox for virus assembly identifies a unique antiviral strategy.},
  author={Eric C. Dykeman and Peter G. Stockley and Reidun Twarock},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 14},
  pages={5361-6}
}
One of the important puzzles in virology is how viruses assemble the protein containers that package their genomes rapidly and efficiently in vivo while avoiding triggering their hosts' antiviral defenses. Viral assembly appears directed toward a relatively small subset of the vast number of all possible assembly intermediates and pathways, akin to Levinthal's paradox for the folding of polypeptide chains. Using an in silico assembly model, we demonstrate that this reduction in complexity can… CONTINUE READING
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