Solving a Levinthal's paradox for virus assembly identifies a unique antiviral strategy.

  title={Solving a Levinthal's paradox for virus assembly identifies a unique antiviral strategy.},
  author={Eric C. Dykeman and Peter G. Stockley and Reidun Twarock},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 14},
One of the important puzzles in virology is how viruses assemble the protein containers that package their genomes rapidly and efficiently in vivo while avoiding triggering their hosts' antiviral defenses. Viral assembly appears directed toward a relatively small subset of the vast number of all possible assembly intermediates and pathways, akin to Levinthal's paradox for the folding of polypeptide chains. Using an in silico assembly model, we demonstrate that this reduction in complexity can… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 34 extracted citations

Recent advances in coarse-grained modeling of virus assembly.

Current opinion in virology • 2016
View 6 Excerpts
Highly Influenced

Strings , Trees , and RNA Folding

View 3 Excerpts
Highly Influenced

The Role of Packaging Sites in Efficient and Specific Virus Assembly.

Journal of molecular biology • 2015
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 56 references

A new paradigm for the roles of the genome in ssRNA viruses

PG Stockley, NA Ranson, R Twarock
Virology • 2013

Building a viral capsid in the presence of genomic RNA.

Physical review. E, Statistical, nonlinear, and soft matter physics • 2013

Similar Papers

Loading similar papers…