Solvent-solute interactions in hydrofluoroalkane propellants.

  title={Solvent-solute interactions in hydrofluoroalkane propellants.},
  author={Robson P S Peguin and Sandro R. P. da Rocha},
  journal={The journal of physical chemistry. B},
  volume={112 27},
Understanding solvation in hydrofluoroalkane (HFA) propellants is of great importance for the development of novel pressurized metered-dose inhaler (pMDI) formulations. HFA-based pMDIs are not only the most widely used inhalation therapy devices for delivering small drug molecules to the respiratory tract, but they also hold promise as vehicles for the delivery of therapeutic biomolecules to and through the lungs. In this work we use binding energy calculations to determine the degree of… CONTINUE READING