• DOI:10.1007/s11094-011-0542-x
• Corpus ID: 32298339

Solvent polarity effect on the composition of biologically active substances, UV spectral characteristics, and antibacterial activity of Euphrasia brevipila herb extracts

@article{Suchinina2011SolventPE,
  title={Solvent polarity effect on the composition of biologically active substances, UV spectral characteristics, and antibacterial activity of Euphrasia brevipila herb extracts},
  author={T. V. Suchinina and T. S. Shestakova and V. M. Petrichenko and Valentina V. Novikova},
  journal={Pharmaceutical Chemistry Journal},
  year={2011},
  volume={44},
  pages={683-686}
}

• T. V. Suchinina, T. S. Shestakova, +1 author V. Novikova
• Published 14 April 2011
• Chemistry
• Pharmaceutical Chemistry Journal

The compositions of biologically active substances in Euphrasia brevipila Burn. et Gremli (Scrophulariaceae) extracts obtained using solvents with different polarities have been investigated. It was established that the composition of isolated substances varied depending on the extractant polarity. Only phenolcarboxylic acids were found in ether, chloroform, and ethylacetate extracts. Aqueous, ethanol, and DMSO extracts contained also flavonoids and iridoids. The difference in the compositions of biologically active substances was confirmed by UV spectral characteristics of extract solutions with added complexants. The maximum antibacterial activity with respect to Staphylococcus aureus and Escherichia coli was observed for extracts obtained using the nonpolar solvents petroleum ether and chloroform (in 1:320 dilution). The bacteriostatic activity of the extracts decreases with increasing solvent polarity in the order n-butanol—ethanol—water—DMSO.