Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution.

  title={Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution.},
  author={C. A. Davey and D. F. Sargent and K. Luger and A. W. M{\"a}der and T. Richmond},
  journal={Journal of molecular biology},
  volume={319 5},
  • C. A. Davey, D. F. Sargent, +2 authors T. Richmond
  • Published 2002
  • Medicine, Chemistry
  • Journal of molecular biology
  • Solvent binding in the nucleosome core particle containing a 147 base pair, defined-sequence DNA is characterized from the X-ray crystal structure at 1.9 A resolution. A single-base-pair increase in DNA length over that used previously results in substantially improved clarity of the electron density and accuracy for the histone protein and DNA atomic coordinates. The reduced disorder has allowed for the first time extensive modeling of water molecules and ions. Over 3000 water molecules and 18… CONTINUE READING
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