Solvent history dependence of gramicidin A conformations in hydrated lipid bilayers.

@article{Lograsso1988SolventHD,
  title={Solvent history dependence of gramicidin A conformations in hydrated lipid bilayers.},
  author={Philip V Lograsso and F Moll and Timothy A. Cross},
  journal={Biophysical journal},
  year={1988},
  volume={54 2},
  pages={259-67}
}
Reconstituted lipid bilayers of dimyristoylphosphatidylcholine (DMPC) and gramicidin A' have been prepared by cosolubilizing gramicidin and DMPC in one of three organic solvent systems followed by vacuum drying and hydration. The conformational state of gramicidin as characterized by 23Na NMR, circular dichroism, and solid state 15N NMR is dependent upon the cosolubilizing solvent system. In particular, two conformational states are described; a state in which Na+ has minimal interactions with… CONTINUE READING

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