Solvent-Exposed Salt Bridges Influence the Kinetics of α-Helix Folding and Unfolding

@inproceedings{Meuzelaar2014SolventExposedSB,
  title={Solvent-Exposed
Salt Bridges Influence the Kinetics
of α-Helix Folding and Unfolding},
  author={Heleen Meuzelaar and Martijn Tros and Adriana Huerta-Viga and Chris Neil van Dijk and Jocelyne Vreede and Sander Woutersen},
  booktitle={The journal of physical chemistry letters},
  year={2014}
}
Salt bridges are known to play an essential role in the thermodynamic stability of the folded conformation of many proteins, but their influence on the kinetics of folding remains largely unknown. Here, we investigate the effect of Glu-Arg salt bridges on the kinetics of α-helix folding using temperature-jump transient-infrared spectroscopy and steady-state… CONTINUE READING