Solvation-assisted pressure tuning of insulin fibrillation: from novel aggregation pathways to biotechnological applications.

Solvation-assisted pressure tuning has been employed to unravel unknown structural and kinetic aspects of the insulin aggregation and fibrillation process. Our approach, using fluorescence, Fourier transform infrared and atomic force microscopy techniques in combination with pressure and solvent perturbation, reveals new insights into the pre-aggregated… CONTINUE READING