Solution structures and biological functions of the antimicrobial peptide, arenicin-1, and its linear derivative.

@article{Lee2007SolutionSA,
  title={Solution structures and biological functions of the antimicrobial peptide, arenicin-1, and its linear derivative.},
  author={Ju-Un Lee and Dong-Il Kang and Wan Long Zhu and Song Yub Shin and Kyung-soo Hahm and Yangmee Kim},
  journal={Biopolymers},
  year={2007},
  volume={88 2},
  pages={208-16}
}
Arenicin-1 (AR-1) is a novel antimicrobial peptide that was isolated from coelomocytes of the marine polychaeta lugworm Arenicola marina and shown to contain a single disulfide bond between Cys3 and Cys20, forming an 18-residue ring [Ovchinnikova, T. V. et al., FEBS Lett 2004, 577, 209-214]. To determine the role of this disulfide bond, we synthesized AR-1 (RWCVYAYVRVRGVLVRYRRCW) and its linear derivative, arenicin-1-S (AR-1-S: RWSVYAYVRVRGVLVRYRRSW). Activity assays revealed that AR-1-S is… CONTINUE READING

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