Solution structure of the variable-type domain of the receptor for advanced glycation end products: new insight into AGE-RAGE interaction.

@article{Matsumoto2008SolutionSO,
  title={Solution structure of the variable-type domain of the receptor for advanced glycation end products: new insight into AGE-RAGE interaction.},
  author={Shigeyuki Matsumoto and Takuya Yoshida and Hiroko Murata and Shusaku Harada and Naoko Fujita and Shota Nakamura and Yasuhiko Yamamoto and Takuo Watanabe and Hideto Yonekura and Hiroshi Yamamoto and Tadayasu Ohkubo and Yuji Kobayashi},
  journal={Biochemistry},
  year={2008},
  volume={47 47},
  pages={12299-311}
}
Diabetes is defined by chronic hyperglycemia due to deficiency in insulin action. It has been found that the amount of advanced glycation end products (AGE) from the Maillard reaction between proteins and sugar molecules increases in blood of diabetic patients and furthermore that AGE binding to their cell surface receptor (RAGE) triggers both macrovascular and microvascular impairments to cause diabetic complications. Due to the clinical significance of the vascular complications, RAGE is… CONTINUE READING

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