Solution structure of the integral human membrane protein VDAC-1 in detergent micelles.

@article{Hiller2008SolutionSO,
  title={Solution structure of the integral human membrane protein VDAC-1 in detergent micelles.},
  author={Sebastian Hiller and Robert G. Garces and Thomas J Malia and Vladislav Yu Orekhov and Marco Colombini and Gerhard Wagner},
  journal={Science},
  year={2008},
  volume={321 5893},
  pages={1206-10}
}
The voltage-dependent anion channel (VDAC) mediates trafficking of small molecules and ions across the eukaryotic outer mitochondrial membrane. VDAC also interacts with antiapoptotic proteins from the Bcl-2 family, and this interaction inhibits release of apoptogenic proteins from the mitochondrion. We present the nuclear magnetic resonance (NMR) solution structure of recombinant human VDAC-1 reconstituted in detergent micelles. It forms a 19-stranded beta barrel with the first and last strand… CONTINUE READING
Highly Influential
This paper has highly influenced 26 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
167 Citations
45 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 167 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Environ. Sci. Technol

  • Y Wang, D K Newman
  • Environ. Sci. Technol
  • 2008

Membrane Proteins of Known 3D Structure

  • S H White
  • Membrane Proteins of Known 3D Structure
  • 2008

Biochemistry

  • T J Malia, G Wagner
  • Biochemistry
  • 2007

ChemBioChem

  • De Pinto
  • ChemBioChem
  • 2007

Philos. Trans. R. Soc. London B Biol. Sci

  • G Yim, H H Wang, J Davies
  • Philos. Trans. R. Soc. London B Biol. Sci
  • 2007

Physiol. Rev

  • G Kroemer, L Galluzzi, C Brenner
  • Physiol. Rev
  • 2007

Streptomyces in Nature and Medicine: The Antibiotic Makers

  • D A Hopwood
  • Streptomyces in Nature and Medicine: The…
  • 2007

Annu. Rev. Phytopathol

  • D V Mavrodi, W Blankenfeldt, L S Thomashow
  • Annu. Rev. Phytopathol
  • 2006

Biochem. Biophys. Res. Commun

  • W Park, S Pena-Llopis, Y Lee, B Demple
  • Biochem. Biophys. Res. Commun
  • 2006

Similar Papers

Loading similar papers…