Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.

@article{Cai2001SolutionSO,
  title={Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.},
  author={Mengli Cai and Yafei Huang and Rodolfo Ghirlando and Katherine L. Wilson and Robert Craigie and G Marius Clore},
  journal={The EMBO journal},
  year={2001},
  volume={20 16},
  pages={4399-407}
}
The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved approximately 40-residue 'LEM' motif. Loss of emerin causes Emery-Dreifuss muscular dystrophy. We have solved the solution NMR structure of the constant region of human LAP2 (residues 1-168). Human LAP2(1-168) has two structurally independent, non-interacting domains located at residues 1-50 ('LAP2-N') and residues 111-152 (LEM-domain), connected by an approximately 60-residue flexible linker. The two domains are structurally… CONTINUE READING
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