Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta.

@article{Zhang2006SolutionSO,
  title={Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta.},
  author={Li Zhang and Michele Derider and Melissa A McCornack and Shu-chuan Jao and Nancy G. Isern and Traci L. Ness and Richard Moyer and Patricia LiWang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 38},
  pages={13985-90}
}
Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP… CONTINUE READING
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