Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1β

  title={Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1β},
  author={L. Zhang and M. Derider and Melissa A McCornack and S. Jao and N. Isern and T. Ness and Richard H. Moyer and P. LiWang},
  journal={Proceedings of the National Academy of Sciences},
  pages={13985 - 13990}
  • L. Zhang, M. Derider, +5 authors P. LiWang
  • Published 2006
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1… CONTINUE READING

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