Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide.

@article{Olah1993SolutionSO,
  title={Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide.},
  author={Glenn Allen Olah and Ronald W. D. Mitchell and Tobin R. Sosnick and Donal A. Walsh and Jill Trewhella},
  journal={Biochemistry},
  year={1993},
  volume={32 14},
  pages={3649-57}
}
Small-angle X-ray scattering and Fourier transform infrared (FTIR) spectroscopy experiments have been completed on the catalytic subunit of the cAMP-dependent protein kinase. Measurements were made both with and without the protein kinase inhibitor peptide, PKI alpha(5-22)amide. Binding of the peptide results in an overall contraction of the structure that… CONTINUE READING