Solution structure of the apical stem–loop of the human hepatitis B virus encapsidation signal

@article{Flodell2006SolutionSO,
  title={Solution structure of the apical stem–loop of the human hepatitis B virus encapsidation signal},
  author={Sara Flodell and Michael Petersen and Fr{\'e}d{\'e}ric Girard and Janusz Zdunek and Karin Kidd-Ljunggren and J{\"u}rgen Schleucher and Sybren Wijmenga},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={4449 - 4457}
}
Hepatitis B virus (HBV) replication is initiated by HBV RT binding to the highly conserved encapsidation signal, epsilon, at the 5' end of the RNA pregenome. Epsilon contains an apical stem-loop, whose residues are either totally conserved or show rare non-disruptive mutations. Here we present the structure of the apical stem-loop based on NOE, RDC and (1)H chemical shift NMR data. The (1)H chemical shifts proved to be crucial to define the loop conformation. The loop sequence 5'-CUGUGC-3… CONTINUE READING

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