Solution structure of the R3H domain from human Smubp-2.

  title={Solution structure of the R3H domain from human Smubp-2.},
  author={Edvards Liepinsh and Ainars Leonchiks and Anatoly Sharipo and Laurent Guignard and Gottfried Otting},
  journal={Journal of molecular biology},
  volume={326 1},
The R3H domain is a conserved sequence motif, identified in over 100 proteins, that is thought to be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA. In this work the 3D structure of the R3H domain from human Smubp-2 was determined by NMR spectroscopy. It is the first 3D structure determination of an R3H domain. The fold presents a small motif, consisting of a three-stranded antiparallel beta-sheet and two alpha-helices, which is related to the structures of the… CONTINUE READING
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