Solution structure of the HIV-2 TAR-argininamide complex.

  title={Solution structure of the HIV-2 TAR-argininamide complex.},
  author={Alexander Brodsky and James R Williamson},
  journal={Journal of molecular biology},
  volume={267 3},
The trans-activating region (TAR) RNA-Tat protein interaction is important for activation of transciption in the human immunodeficiency virus (HIV). A model complex for this interaction composed of the two base bulge HIV-2 TAR and the amide derivative of arginine was studied by multidimensional heteronuclear NMR. Because of the improved spectral properties of the HIV-2 TAR complex, a larger number of NOEs in the bulge region were observed than in earlier studies of the HIV-1 TAR-argininamide… CONTINUE READING
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