Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module

@inproceedings{Wang2013SolutionSO,
  title={Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module},
  author={Tao Wang and Jiahai Zhang and Xuecheng Zhang and Chao Xu and Xiaoming Tu},
  booktitle={Scientific reports},
  year={2013}
}
Streptococcus pneumoniae is a pathogen causing acute respiratory infection, otitis media and some other severe diseases in human. In this study, the solution structure of a bacterial immunoglobulin-like (Big) domain from a putative S. pneumoniae surface protein SP0498 was determined by NMR spectroscopy. SP0498 Big domain adopts an eight-β-strand barrel-like fold, which is different in some aspects from the two-sheet sandwich-like fold of the canonical Ig-like domains. Intriguingly, we… CONTINUE READING
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