Solution structure of the BRK domains from CHD7.

  title={Solution structure of the BRK domains from CHD7.},
  author={Mark D. Allen and Tomasz L. Religa and Stefan Freund and Mark Bycroft},
  journal={Journal of molecular biology},
  volume={371 5},
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second… CONTINUE READING
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