Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA.

@article{Bourbigot2016SolutionSO,
  title={Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA.},
  author={Sarah Bourbigot and Anne-Catherine Dock-Br{\'e}geon and Pascal Eberling and J{\'e}r{\^o}me Coutant and Bruno Kieffer and Isabelle Lebars},
  journal={RNA},
  year={2016},
  volume={22 12},
  pages={1844-1858}
}
The small nuclear 7SK RNA regulates RNA polymerase II (RNA Pol II) transcription, by sequestering and inhibiting the positive transcription elongation factor b (P-TEFb). P-TEFb is stored in the 7SK ribonucleoprotein (RNP) that contains the three nuclear proteins Hexim1, LaRP7, and MePCE. P-TEFb interacts with the protein Hexim1 and the 7SK RNA. Once P-TEFb is released from the 7SK RNP, it activates transcription by phosphorylating the C-terminal domain of RNA Pol II. P-TEFb also plays a crucial… CONTINUE READING