Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

@article{Day2005SolutionSO,
  title={Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.},
  author={Catherine L Day and Li-li Chen and Sarah J. Richardson and Penny J Harrison and David C S Huang and Mark G. Hinds},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 6},
  pages={4738-44}
}
The B cell lymphoma-2 (Bcl-2) homologs myeloid cell leukemia-1 (Mcl-1) and A1 are prosurvival factors that selectively bind a subset of proapoptotic Bcl homology (BH) 3-only proteins. To investigate the molecular basis of the selectivity, we determined the solution structure of the C-terminal Bcl-2-like domain of Mcl-1. This domain shares features expected of a prosurvival Bcl-2 protein, having a helical fold centered on a core hydrophobic helix and a surface-exposed hydrophobic groove for… CONTINUE READING

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