Solution structure of human proinsulin C‐peptide

@article{Munte2005SolutionSO,
  title={Solution structure of human proinsulin C‐peptide},
  author={C. Munte and L. Vilela and H. Kalbitzer and R. Garratt},
  journal={The FEBS Journal},
  year={2005},
  volume={272}
}
The C‐peptide of proinsulin is important for the biosynthesis of insulin, but has been considered for a long time to be biologically inert. Recent studies in diabetic patients have stimulated a new debate about its possible regulatory role, suggesting that it is a hormonally active peptide. We describe structural studies of the C‐peptide using 2D NMR spectroscopy. In aqueous solution, the NOE patterns and chemical shifts indicate that the ensemble is a nonrandom structure and contains… Expand
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