Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance.

  title={Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance.},
  author={John Gehrmann and Norelle L Daly and Paul F Alewood and David J. Craik},
  journal={Journal of medicinal chemistry},
  volume={42 13},
alpha-Conotoxin ImI derives from the venom of Conus imperialis and is the first and only small-peptide ligand that selectively binds to the neuronal alpha7 homopentameric subtype of the nicotinic acetylcholine receptor (nAChR). This receptor subtype is a possible drug target for several neurological disorders. The cysteines are connected in the pairs Cys2-Cys8 and Cys3-Cys12. To date it is the only alpha-conotoxin with a 4/3 residue spacing between the cysteines. The structure of ImI has been… CONTINUE READING


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