Solution structure of a viral DNA polymerase X and evidence for a mutagenic function

  title={Solution structure of a viral DNA polymerase X and evidence for a mutagenic function},
  author={Alexander K. Showalter and In-Ja L. Byeon and Mei-I. Su and Ming-Daw Tsai},
  journal={Nature Structural Biology},
The African swine fever virus DNA polymerase X (ASFV Pol X or Pol X), the smallest known nucleotide polymerase, has recently been reported to be an extremely low fidelity polymerase that may be involved in strategic mutagenesis of the viral genome. Here we report the solution structure of Pol X. The structure, unique within the realm of nucleotide polymerases, consists of only palm and fingers subdomains. Despite the absence of a thumb subdomain, which is important for DNA binding in other… CONTINUE READING
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