Solution structure of a truncated anti-MUC1 DNA aptamer determined by mesoscale modeling and NMR.


Mucin 1 is a well-established target for the early diagnosis of epithelial cancers. The nucleotides of the S1.3/S2.2 DNA aptamer involved in binding to variable number tandem repeat mucin 1 peptides have been identified using footprinting experiments. The majority of these binding nucleotides are located in the 25-nucleotide variable region of the total… (More)
DOI: 10.1111/j.1742-4658.2011.08440.x


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