Solution structure of a telomeric DNA complex of human TRF1.

  title={Solution structure of a telomeric DNA complex of human TRF1.},
  author={Taichi Nishikawa and Hideyasu Okamura and Aritaka Nagadoi and Peter K{\"o}nig and Denise A Rhodes and Yoshifumi Nishimura},
  volume={9 12},
BACKGROUND Mammalian telomeres consist of long tandem arrays of double-stranded TTAGGG sequence motif packaged by TRF1 and TRF2. In contrast to the DNA binding domain of c-Myb, which consists of three imperfect tandem repeats, DNA binding domains of both TRF1 and TRF2 contain only a single Myb repeat. In a DNA complex of c-Myb, both the second and third repeats are closely packed in the major groove of DNA and recognize a specific base sequence cooperatively. RESULTS The structure of the DNA… CONTINUE READING


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