Solution structure of a purine.purine.pyrimidine DNA triplex containing G.GC and T.AT triples.

@article{Radhakrishnan1993SolutionSO,
  title={Solution structure of a purine.purine.pyrimidine DNA triplex containing G.GC and T.AT triples.},
  author={Ishwar Radhakrishnan and Dinshaw J. Patel},
  journal={Structure},
  year={1993},
  volume={1 2},
  pages={135-52}
}
BACKGROUND Oligonucleotide-directed triple helix formation allows sequence specific recognition of double helical DNA. This powerful approach has been used to inhibit gene transcription in vitro and to mediate single site specific cleavage of a human chromosome. RESULTS Using a combined NMR and molecular dynamics approach (including relaxation matrix… CONTINUE READING