Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state.

Abstract

Staphylococcus aureus CzrA is a zinc-dependent transcriptional repressor from the ubiquitous ArsR family of metal sensor proteins. Zn(II) binds to a pair of intersubunit C-terminal alpha5-sensing sites, some 15 A distant from the DNA-binding interface, and allosterically inhibits DNA binding. This regulation is characterized by a large allosteric coupling… (More)
DOI: 10.1073/pnas.0905558106

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@article{Arunkumar2009SolutionSO, title={Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state.}, author={Alphonse Ignatius Arunkumar and Gregory C. Campanello and David P Giedroc}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2009}, volume={106 43}, pages={18177-82} }