Solution structure of a green mamba toxin that activates muscarinic acetylcholine receptors, as studied by nuclear magnetic resonance and molecular modeling.

@article{Sgalas1995SolutionSO,
  title={Solution structure of a green mamba toxin that activates muscarinic acetylcholine receptors, as studied by nuclear magnetic resonance and molecular modeling.},
  author={I S{\'e}galas and C Roumestand and Sophie Zinn-Justin and Bernard Gilquin and Ren{\'e}e M{\'e}nez and Andr{\'e} M{\'e}nez and Flavio Toma},
  journal={Biochemistry},
  year={1995},
  volume={34 4},
  pages={1248-60}
}
The three-dimensional solution structure of the MTX2 toxin (65 amino acids and 4 disulfides) from the green mamba venom (Dendroaspis angusticeps), a toxin that activates the pharmacological M1 muscarinic acetylcholine receptors, has been determined by nuclear magnetic resonance and molecular modeling. Seventeen structures were calculated from 810 distance and 68 dihedral angle restraints using DIANA and X-PLOR. The average rms deviation between the 17 refined structures and the energy-minimized… CONTINUE READING

Similar Papers

Loading similar papers…