Solution structure of a core peptide derived from scyllatoxin.

  title={Solution structure of a core peptide derived from scyllatoxin.},
  author={Matthew D. Pagel and David E Wemmer},
  volume={18 3},
An analysis of the sequences of scyllatoxin and charybdotoxin suggested that it would be possible to design a core peptide sequence which would still fold to give the beta-hairpin and helix seen in the toxins, but which would eliminate one disulfide and connecting residues. The core sequence was modeled, then synthesized and purified. The cysteines oxidize in air to give the same disulfide pairings as seen in the parent toxins as the major product. The three-dimensional structure of the core… CONTINUE READING