Solution structure of Phl p 3, a major allergen from timothy grass pollen.

  title={Solution structure of Phl p 3, a major allergen from timothy grass pollen.},
  author={Kristian Schweimer and Arnd Petersen and Roland Suck and W Becker and Paul R{\"o}sch and Irena Matecko},
  journal={Biological chemistry},
  volume={389 7},
The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determined by nuclear magnetic resonance spectroscopy reveals that the protein consists of a core of hydrophobic amino-acid side chains from two beta-sheets of five and four anti-parallel beta-strands, respectively. This conformation is very similar to the crystal… CONTINUE READING


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