Solution structure of Ca2+–calmodulin reveals flexible hand-like properties of its domains

@article{Chou2001SolutionSO,
  title={Solution structure of Ca2+–calmodulin reveals flexible hand-like properties of its domains},
  author={James J. Chou and Shipeng Li and Claude B. Klee and Adriaan Bax},
  journal={Nature Structural Biology},
  year={2001},
  volume={8},
  pages={990-997}
}
The solution structure of Ca2+-ligated calmodulin is determined from residual dipolar couplings measured in a liquid crystalline medium and from a large number of heteronuclear J couplings for defining side chains. Although the C-terminal domain solution structure is similar to the X-ray crystal structure, the EF hands of the N-terminal domain are considerably less open. The substantial differences in interhelical angles correspond to negligible changes in short interproton distances and… CONTINUE READING