Solution structure of 6aJL2 and 6aJL2-R24G amyloidogenics light chain proteins.

@article{MayaMartinez2015SolutionSO,
  title={Solution structure of 6aJL2 and 6aJL2-R24G amyloidogenics light chain proteins.},
  author={Roberto Maya-Martinez and Paloma C. Gil-Rodr{\'i}guez and Carlos Amero},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={456 2},
  pages={695-9}
}
AL amyloidosis is the most common amyloid systemic disease and it is characterized by the deposition of immunoglobulin light chain amyloid fibers in different organs, causing organ failure. The immunoglobulin light chain germinal line 6a has been observed to over-express in AL patients, moreover, it was observed that, out of these amyloidogenic proteins, 25% present a mutation of an Arg to Gly in position 24. In vitro studies have shown that this mutation produces proteins with a higher amyloid… CONTINUE READING

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