Solution structure determination of endothelin-1 in methanol/water by NMR and molecular modelling methods.

@article{Hewage1997SolutionSD,
  title={Solution structure determination of endothelin-1 in methanol/water by NMR and molecular modelling methods.},
  author={Chandralal M. Hewage and Lu Jiang and John A. Parkinson and Robert Ramage and I. Sadler},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={1997},
  volume={3 6},
  pages={415-28}
}
To understand the structural requirements for the biological activity of endothelin peptides and to develop receptor selective endothelin analogues further, the solution structure of the bicyclic 21 amino acid residue vasoactive peptide, endothelin-1, has been determined in methanol-d3/water using high-resolution 1H-NMR spectroscopy. To our knowledge, this… CONTINUE READING