Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR).

  title={Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR).},
  author={Ming Zhou and David A Horita and David S Waugh and Richard Byrd and Deborah K. Morrison},
  journal={Journal of molecular biology},
  volume={315 3},
Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that acts as a molecular scaffold to promote signal transmission from Raf-1 to MEK and MAPK. All KSR proteins contain a conserved cysteine-rich C1 domain, and studies have implicated this domain in the regulation of KSR1 subcellular localization and function. To further elucidate the biological role of the KSR1 C1 domain, we have determined its three-dimensional solution structure using nuclear magnetic resonance (NMR… CONTINUE READING


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