Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus.

@article{McDonnell1998SolutionSA,
  title={Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus.},
  author={James M McDonnell and David Fushman and Sean M. Cahill and Wenbo Zhou and Amy K. Wolven and Carol B. Wilson and Timothy Nelle and Marilyn D. Resh and Jonathan Wills and David Cowburn},
  journal={Journal of molecular biology},
  year={1998},
  volume={279 4},
  pages={921-8}
}
A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The… CONTINUE READING

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