Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states

@article{Bertini2009SolutionSA,
  title={Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states},
  author={Ivano Bertini and Soumyasri Das Gupta and Xiaoyu Hu and Tilemachos Karavelas and Claudio Luchinat and Giacomo Parigi and Jing Yuan},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2009},
  volume={14},
  pages={1097-1107}
}
S100A5 is a calcium binding protein of the S100 family, with one canonical and one S100-specific EF-hand motif per subunit. Although its function is still unknown, it has recently been reported to be one of the S100 proteins able to interact with the receptor for advanced glycation end products. The homodimeric solution structures of S100A5 in both the apo and the calcium(II)-loaded forms have been obtained, and show a conformational rearrangement upon calcium binding. This rearrangement… CONTINUE READING