Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.

@article{Li2003SolutionSA,
  title={Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.},
  author={Qing Li and Chaitan Khosla and Joseph D. Puglisi and Corey W. Liu},
  journal={Biochemistry},
  year={2003},
  volume={42 16},
  pages={4648-57}
}
During polyketide biosynthesis, acyl carrier proteins (ACPs) perform the central role of transferring polyketide intermediates between active sites of polyketide synthase. The 4'-phosphopantetheine prosthetic group of a holo-ACP is a long and flexible arm that can reach into different active sites and provide a terminal sulfhydryl group for the attachment of acyl groups through a thioester linkage. We have determined the solution structure and characterized backbone dynamics of the holo form of… CONTINUE READING