Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols.

@article{Mercalli2014SolutionphasePS,
  title={Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols.},
  author={Valentina Mercalli and M. Giustiniano and E. Del Grosso and M. Varese and Hilde Cassese and A. Massarotti and E. Novellino and G. Tron},
  journal={ACS combinatorial science},
  year={2014},
  volume={16 11},
  pages={
          602-5
        }
}
A library of 41 aryloxyimino amides was prepared via solution phase parallel synthesis by extending the multicomponent reaction of (Z)-chlorooximes and isocyanides to the use of electron-deficient phenols. The resulting aryloxyiminoamide derivatives can be used as intermediates for the synthesis of benzo[d]isoxazole-3-carboxamides, dramatically reducing the number of synthetic steps required by other methods reported in literature. 
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