Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength.

@article{Sule2012SolutionPT,
  title={Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength.},
  author={Shantanu V Sule and Jason K. Cheung and Valentyn Antochshuk and Amardeep S Bhalla and Chakravarthy Narasimhan and Steven J. Blaisdell and Mohammed Shameem and Peter M Tessier},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 4},
  pages={744-51}
}
Monoclonal antibodies display highly variable solution properties such as solubility and viscosity at elevated concentrations (>50 mg/mL), which complicates antibody formulation and delivery. To understand this complex behavior, it is critical to measure the underlying protein self-interactions that govern the solution properties of antibody suspensions. We have evaluated the pH-dependent self-association behavior of three monoclonal antibodies using self-interaction chromatography for a range… CONTINUE READING
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