Solution of a protein crystal structure with a model obtained from NMR interproton distance restraints.

@article{Brnger1987SolutionOA,
  title={Solution of a protein crystal structure with a model obtained from NMR interproton distance restraints.},
  author={Axel T. Br{\"u}nger and Robert L. Campbell and G Marius Clore and Angela M. Gronenborn and Martin Karplus and Gregory A. Petsko and Martha M. Teeter},
  journal={Science},
  year={1987},
  volume={235 4792},
  pages={1049-53}
}
Model calculations were performed to test the possibility of solving crystal structures of proteins by Patterson search techniques with three-dimensional structures obtained from nuclear magnetic resonance (NMR) interproton distance restraints. Structures for crambin obtained from simulated NMR data were used as the test system; the root-mean-square deviations of the NMR structures from the x-ray structure were 1.5 to 2.2 A for backbone atoms and 2.0 to 2.8 A for side-chain atoms. Patterson… CONTINUE READING

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