Solution-mediated phase transformation: significance during dissolution and implications for bioavailability.

Abstract

Solubility improvement of poorly soluble drug compounds is a key approach to ensuring the successful development of many new drugs. Methods used to improve the solubility of drug compounds include forming a salt, cocrystal, or amorphous solid. These methods of improving solubility can often lead to a phenomenon called solution-mediated phase transformation… (More)
DOI: 10.1002/jps.23025

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Cite this paper

@article{Greco2012SolutionmediatedPT, title={Solution-mediated phase transformation: significance during dissolution and implications for bioavailability.}, author={Kristyn Greco and Robin Bogner}, journal={Journal of pharmaceutical sciences}, year={2012}, volume={101 9}, pages={2996-3018} }