Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity.

@article{Enyedy2013SolutionEO,
  title={Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity.},
  author={{\'E}. A. Enyedy and {\'E}va Sija and T. Jakusch and C. Hartinger and W. Kandioller and B. Keppler and T. Kiss},
  journal={Journal of inorganic biochemistry},
  year={2013},
  volume={127},
  pages={
          161-8
        }
}
  • É. A. Enyedy, Éva Sija, +4 authors T. Kiss
  • Published 2013
  • Chemistry, Medicine
  • Journal of inorganic biochemistry
  • Stoichiometry and stability of antitumor ruthenium(II)-η(6)-p-cymene complexes of bidentate (O,O) hydroxypyrone and (O,S) hydroxythiopyr(id)one type ligands were determined by pH-potentiometry, (1)H NMR spectroscopy and UV-Vis spectrophotometry in aqueous solution and in dependence of chloride ion concentration. Formation of mono-ligand complexes with moderate stability was found in the case of the hydroxypyrone ligands (ethyl maltol and allomaltol) predominating at the physiological pH range… CONTINUE READING
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