Solution conformational analysis of amphiphilic helical, synthetic analogs of the lipopeptaibol trichogin GA IV.

@article{Monaco1998SolutionCA,
  title={Solution conformational analysis of amphiphilic helical, synthetic analogs of the lipopeptaibol trichogin GA IV.},
  author={Vania Monaco and Elsa Locardi and Fernando Formaggio and Marco Crisma and Stefano Mammi and Evaristo Peggion and C. Toniolo and Sylvie Rebuffat and Bernard Bodo},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={1998},
  volume={52 4},
  pages={261-72}
}
The step-by-step synthesis by solution methods of the [Ser2,5,6,9, Leu-OMe11] analog of trichogin GA IV is described. The four Ser residues have been incorporated into the sequence as replacements of the naturally occurring Gly residues to increase the amphiphilicity of the 3D-structure of the lipopeptaibol. A detailed solution conformational analysis has… CONTINUE READING