Solution conformation of an RNA--DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand.

@article{Hantz2001SolutionCO,
  title={Solution conformation of an RNA--DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand.},
  author={Edith Hantz and Val{\'e}ry Larue and Patrick Ladam and Laurence Le Moyec and Catherine Gouyette and T Huynh Dinh},
  journal={International journal of biological macromolecules},
  year={2001},
  volume={28 4},
  pages={273-84}
}
RNA--DNA hybrid duplexes are involved in transcription, replication and reverse transcription of nucleic acids. Information on such duplexes may shed some light on the mechanism of these processes. For this purpose, the influence of base composition on the structure of a polypyrimidine--polypurine RNA--DNA duplex r(cucuccuucucuu). d(GAGAGGAAGAGAA) has been studied using 1H, 31P and 13C NMR experiments, molecular modeling (JUMNA program) and NOE back-calculation methods. The resulting structure… CONTINUE READING

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