Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65.

@article{Jenkins2008SolutionCA,
  title={Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65.},
  author={Jermaine L. Jenkins and Haihong Shen and Michael R. Green and Clara L Kielkopf},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 48},
  pages={33641-9}
}
The U2 auxiliary factor large subunit (U2AF65) is an essential pre-mRNA splicing factor for the initial stages of spliceosome assembly. Tandem RNA recognition motifs (RRM)s of U2AF65 recognize polypyrimidine tract signals adjacent to 3' splice sites. Despite the central importance of U2AF65 for splice site recognition, the relative arrangement of the U2AF65… CONTINUE READING