Solution Thermodynamics and Kinetics of Metal Complexation with a Hydroxypyridinone Chelator Designed for Thorium-227 Targeted Alpha Therapy.

  title={Solution Thermodynamics and Kinetics of Metal Complexation with a Hydroxypyridinone Chelator Designed for Thorium-227 Targeted Alpha Therapy.},
  author={Gauthier J.-P. Deblonde and Trevor D. Lohrey and Corwin H. Booth and Korey P. Carter and Bernard F. Parker and {\AA}smund Larsen and Roger Smeets and Olav B. Ryan and Alan S. Cuthbertson and Rebecca J. Abergel},
  journal={Inorganic chemistry},
  volume={57 22},
The solution chemistry of a chelator developed for 227Th targeted alpha therapy was probed. The compound of interest is an octadentate ligand comprising four N-methyl-3-hydroxy-pyridine-2-one metal-binding units, two tertiary amine groups, and one carboxylate arm appended for bioconjugation. The seven p Ka values of the ligand and the stability constants of complexes formed with Th(IV), Hf(IV), Zr(IV), Gd(III), Eu(III), Al(III), and Fe(III) were determined. The ligand exhibits extreme… 

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