Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

@inproceedings{Makou2012SolutionSO,
  title={Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H},
  author={Elisavet Makou and Haydyn D T Mertens and Mateusz Maciejewski and Dinesh C Soares and Ilias Matis and Christoph Q. Andreas Schmidt and Andrew Herbert and Dmitri I. Svergun and Paul N. Barlow},
  booktitle={Journal of molecular biology},
  year={2012}
}
The 155-kDa plasma glycoprotein factor H (FH), which consists of 20 complement control protein (CCP) modules, protects self-tissue but not foreign organisms from damage by the complement cascade. Protection is achieved by selective engagement of FH, via CCPs 1-4, CCPs 6-8 and CCPs 19-20, with polyanion-rich host surfaces that bear covalently attached… CONTINUE READING