Solution Structure and Dynamics of the I214V Mutant of the Rabbit Prion Protein

  title={Solution Structure and Dynamics of the I214V Mutant of the Rabbit Prion Protein},
  author={Yi Wen and Jun Li and Minqian Xiong and Yu Peng and Wenming Yao and Jing Hong and Donghai Lin},
  booktitle={PloS one},
BACKGROUND The conformational conversion of the host-derived cellular prion protein (PrP(C)) into the disease-associated scrapie isoform (PrP(Sc)) is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs). Various single-point mutations in PrP(C)s could cause structural changes and thereby distinctly influence the conformational conversion. Elucidation of the differences between the wild-type rabbit PrP(C) (RaPrP(C)) and various mutants would be of great help to… CONTINUE READING
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