Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation.

@article{Greenfield2006SolutionNS,
  title={Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation.},
  author={Norma J. Greenfield and Yuanpeng Janet Huang and G. V. T. Swapna and Aneerban Bhattacharya and Brian A Rapp and Abhishek Singh and Gaetano T. Montelione and Sarah E. Hitchcock-DeGregori},
  journal={Journal of molecular biology},
  year={2006},
  volume={364 1},
  pages={80-96}
}
Tropomyosin is a coiled-coil protein that binds head-to-tail along the length of actin filaments in eukaryotic cells, stabilizing them and providing protection from severing proteins. Tropomyosin cooperatively regulates actin's interaction with myosin and mediates the Ca2+ -dependent regulation of contraction by troponin in striated muscles. The N-terminal and C-terminal ends are critical functional determinants that form an "overlap complex". Here we report the solution NMR structure of an… CONTINUE READING