Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase.

@article{Massi2006SolutionNA,
  title={Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase.},
  author={Francesca Massi and Chunyu Wang and Arthur G. Palmer},
  journal={Biochemistry},
  year={2006},
  volume={45 36},
  pages={10787-94}
}
Solution NMR spin relaxation experiments and classical MD simulations are used to study the dynamics of triosephosphate isomerase (TIM) in complex with glycerol 3-phosphate (G3P). Three regions in TIM exhibit conformational transitions on the micros-ms time scale as detected by chemical exchange broadening effects in NMR spectroscopy: residue Lys 84 on… CONTINUE READING